Couples' KAP Replay: Module 4, Dyadic Dosing

CE Hours 3

About this course

Overview:

The Couple's KAP Replay is an on-demand continuing education series featuring recordings from Enamory Institute's live Couples' Ketamine-Assisted Psychotherapy (KAP) Therapist Training event held in July 2026. Through didactic instruction, clinical case examples, experiential exercises, and demonstrations, participants are provided with a structured and evidence-based approach to assessment, preparation, dosing, and integration phases of KAP with couples.

Grounded in evidence-based principles and strategies from the established couple therapy literature (Jackson et al., 2026) and informed by current research and best practices in psychedelic-assisted care, this training explores how ketamine can be thoughtfully integrated into couple therapy. Across the series, participants will learn to uncover recurring relational patterns, identify and provide feedback on relevant ketamine treatment targets, prepare couples for ketamine experiences, differentiate approaches to dyadic dosing, and facilitate targeted integration strategies to support couple therapy goals and ongoing relational change.

This training is designed to be applicable across theoretical orientations, emphasizing evidence-based couple therapy principles and structured clinical decision-making that participants can incorporate within their existing approach to working with couples. Whether taken individually or as part of the complete Couples’ KAP replay series, each module (Relational Assessment, Feedback & Preparation, Dyadic Dosing, and Dyadic Integration) provides focused instruction and practical strategies that clinicians can immediately apply in their work with couples.

The following module provides focused instruction on one core component of KAP with couples: Dyadic Dosing, examining the clinical considerations that inform the selection and implementation of dosing approaches for couples.

Module 4: Dyadic Dosing

Module 4, Dyadic Dosing, provides a framework to help therapists match dosing models to the couple’s pattern, goals, preferences, and prescriber recommendations. In this module, we differentiate Solo, Dual psychedelic, Dual psycholytic, and Ketamine-Augmented Couple Therapy models; addresses logistics (in-clinic vs. at-home; therapist-guided vs. self-guided); and explore how dosing may shift over time as therapy progresses.

Learning Objectives

Differentiate among Solo, Dual (psychedelic), Dual (psycholytic), and Ketamine-Augmented Couple Therapy, including indications and cautions for each.
Address setting logistics (in-clinic vs. at-home; therapist-guided vs. self-guided).
Select an initial dosing model that aligns with assessment findings and justify the choice.
Plan dose/model adjustments over time to support treatment milestones.

Learning Levels

Intermediate

Target Audience

This training is suitable for clinicians and other mental health professionals with foundational knowledge of both ketamine-assisted psychotherapy (KAP) and couples therapy.

Course Instructor(s)

Kayla Knopp, PhD

Licensed Clinical Psychologist

Kayla C. Knopp, Ph.D., is a licensed clinical psychologist and clinical researcher. Her research and clinical interests center around understanding the reciprocal associations between intimate relationship functioning and mental health, supporting diverse relationship types and structures, and using novel and creative methods to improve both access to and impacts of interventions for couples. Her current projects include technology-supported interventions for couples and psychedelic-assisted couple therapies. Dr. Knopp earned her Ph.D. in Clinical Psychology from the University of Denver and completed her predoctoral internship and postdoctoral fellowship (Advanced Fellowship for Women’s Health) at the VA San Diego / University of California San Diego consortium. She was awarded a VA Career Development Award under mentorship of Dr. Leslie Morland studying the OurRelationship program for veterans and their partners. Dr. Knopp co-founded Enamory, a clinic, training institute, and research foundation specializing in ketamine-assisted couple therapy. In addition to seeing a small caseload of couples and individuals, Dr. Knopp supervises associate therapists, provides training and consultation to therapists, and conducts clinic-based research. Together with Enamory’s co-founder Dr. Chandra Khalifian and training director Dr. Skylar Kelsven, Dr. Knopp is the co-developer of the world’s first ketamine-assisted couple therapy training and certification program.
Chandra Estelle Khalifian, PhD

Licensed Clinical Psychologist

Chandra Estelle Khalifian, Ph.D., is research faculty at the University of California, San Diego (UCSD) and the co-founder of Enamory– a clinic, training institute, and research center focused on psychedelic-assisted couple therapy. She earned her Ph.D. in Clinical Psychology from the University of Maryland, Baltimore County and completed her predoctoral internship and postdoctoral fellowship (Advanced Fellowship for Women’s Health) at the VA San Diego / UCSD consortium. She completed a VA Career Development Award under mentorship of Dr. Leslie Morland studying the Treatment for Relationships & Saftey (TR&ST)-- a couple-based suicide intervention that she developed during her postdoctoral fellowship. She has been a co-investigator on multiple funded research trials including a MDMA-assisted couple therapy for PTSD trial. Her research is focused on developing novel couple interventions for relationship distress, PTSD, and suicide. She is particularly interested in enhancing evidence-based interventions with psychedelics. Within Enamory, Dr. Khalifian sees couples and individuals, supervises associate therapists, conducts research, and co-developed, with her colleagues, Dr. Kayla Knopp and Dr. Skylar Kelsven, the world’s first ketamine-assisted couple therapy training and certification program.

Disclosure

DISCLOSURE OF RELEVANT FINANCIAL RELATIONSHIPS CE Learning Systems adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Medical Education. Any individuals in a position to control the content of a CE activity ― including faculty, planners, reviewers, or others ― are required to disclose all relevant financial relationships with ineligible entities (formerly known as commercial interests). The following relevant financial relationships have been disclosed by this activity’s planners, faculty, and the reviewer: PLANNERS AND REVIEWER The planners of this activity have reported that they have no relevant financial relationships. FACULTY The faculty of this activity have reported that they have no relevant financial relationships.

References

Askariyan, K., Joghataei, M. T., Dehghan, S., Nohesara, S., Rihipour, L., Mohammadi, M. H., & Ahmadirad, N. (2025). An overview of psilocybin, LSD, MDMA, and ketamine in revitalizing psychedelic-assisted therapy: Insights, limitations and future directions. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 111461. https://doi.org/10.1016/j.pnpbp.2021.111461
Batievsky, D., Weiner, M., Kaplan, S. B., Thase, M. E., Maglione, D. N., & Vidot, D. C. (2023). Ketamine-assisted psychotherapy treatment of chronic pain and comorbid depression: A pilot study of two approaches. Frontiers in Pain Research, 4, 1127863. https://doi.org/10.3389/fpain.2023.1127863
De Gregorio, D., Aguilar-Valles, A., Preller, K. H., Heifets, B. D., Hibicke, M., Mitchell, J., & Gobbi, G. (2021). Hallucinogens in mental health: Preclinical and clinical studies on LSD, psilocybin, MDMA, and ketamine. Journal of Neuroscience, 41(5), 891–900. https://doi.org/10.1523/JNEUROSCI.1659-20.2020
Herzog, R., Mediano, P. A. M., Rosas, F. E., Lodder, P., & Carhart-Harris, R. L. (2023). A mechanistic account of psychedelic-induced subjective effects using network control theory. Scientific Reports, 13(1), 6244. https://doi.org/10.1038/s41598-023-33357-0
Wolfson, P., & Vaid, G. (2024). Ketamine-assisted psychotherapy, psychedelic methodologies, and the impregnable value of the subjective—a new and evolving approach. Frontiers in Psychiatry, 15, 1209419. https://doi.org/10.3389/fpsyt.2024.1209419
Khalifian, C., Rashkovsky, K., Mitchell, E., Bismark, A., Wagner, A. C., & Knopp, K. C. (2024). A novel framework for ketamine-assisted couple therapy. Frontiers in Psychiatry, 15, 1376646. https://doi.org/10.3389/fpsyt.2024.1376646
Cornfield, M., McBride, S., La Torre, J. T., Zalewa, D., Gallo, J., Mahammadli, M., & Williams, M. T. (2024). Exploring effects and experiences of ketamine in group couples therapy. Journal of Psychedelic Studies, 8(2), 233–247. https://doi.org/10.1556/2054.2024.00302
Jackson, J. B., Codecá, L., Miller, R. B., Simpson, J. E., O’Leary, A. M., & Renner, S. M. (2026). Empirically supported couple therapy models for couple relationship distress: A replication and update. Journal of Marital & Family Therapy, 52(4), e70162. https://doi.org/10.1111/jmft.70162

CE Process Info

Content

Handouts- Module 4, Dyadic Dosing

3 parts
- Slide Handout- Module 4, Dyadic Dosing
- Completed Relational Patterns Handout: Case 1 & 2
- Couples' KAP Quick Reference Handout
Dyadic Dosing Part 1

2 parts
- Dyadic Dosing Video 1
- Dosing Models
Dyadic Dosing Part 2

2 parts
- Dyadic Dosing Video 2
- Practice On Your Own
Dyadic Dosing Part 3

1 parts
- Dyadic Dosing Video 3

Joint Accreditation (JA)

In support of improving patient care, CE Learning Systems is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
American Psychological Association (APA)

Continuing Education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP office maintains responsibility for the content of the programs.
New York Education Department's State Board for Social Work (NYEDSW)

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New York Education Department for Licensed Mental Health Counselors (NYSEDLMHC)

CE Learning Systems, LLC (d/b/a impactce.com) is recognized by the New York State Education Department's State Board for Mental Health Practitioners as an approved provider of continuing education for licensed mental health counselors. #MHC-0072.
New York State Education Department's State Board for Psychology (NYEDPSY)

CE Learning Systems, LLC (d/b/a impactce.com) is recognized by the New York State Education Department's State Board for Psychology as an approved provider of continuing education for licensed psychologists. #PSY-0016.
New York Education Department's State Board for Marriage and Family Therapy (NYEDMFT)

CE Learning Systems, LLC (d/b/a impactce.com) is recognized by the New York State Education Department's State Board for Marriage and Family Therapy as an approved provider of continuing education for licensed marriage and family therapists. #MFT-0045.

Couples' KAP Replay: Module 4, Dyadic Dosing

About this course

Learning Objectives

Learning Levels

Target Audience

Course Instructor(s)

Disclosure

References

CE Process Info

Content

Joint Accreditation (JA)

American Psychological Association (APA)

New York Education Department's State Board for Social Work (NYEDSW)

New York Education Department for Licensed Mental Health Counselors (NYSEDLMHC)

New York State Education Department's State Board for Psychology (NYEDPSY)

New York Education Department's State Board for Marriage and Family Therapy (NYEDMFT)

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